Valentin Bragin (1), Gjumrakch Aliev. The Role of Oxidative Stress, Mitochondria Failure, and Cellular Hypoperfusion in the Context of Alzheimer Disease, 2010, 317- 323
Abstract: A study was done on 35 medically ill patients (20 male, 15 female) with an average age of 71.05 with mild dementia and depression in order to evaluate the efficacy of an integrative treatment approach on cognitive performance. These patients were evaluated at baseline and after 6, 12, and 24 months of treatment, which included antindepressants (Sertraline, Citalopram or Venlafaxine XR, alone or in combination with Bupropion XR), cholinesterase inhibitors (Donepezzil, Rivastigmine or Galantamine), as well as vitamins and supplements (Multivitamins, Vitamin E, Alphlipoic Acid, Omega 3 and Coenzyme Q-10). Patients were encouraged to modify their diet and lifestyle and perform mild physical exercises. Results show that the integrative treatment not only protracted cognitive decline for 24 months, but even improved cognition, especially memory and frontal lobe functions.