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Progression of cognitive function after integrated treatment approach in demented and clinically depressed patients

Valentin Bragin (1), Gjumrakch Aliev (1-4). The Role of Oxidative Stress, Mitochondria Failure, and Cellular Hypoperfusion in the Context of Alzheimer Disease, 2010, 317- 323

  1. Stress Relief and Memory Training Center, Brooklyn, NY 11235, USA; (2) Department of Biology College of Sciences and (3) Electron Microscopy Research Center, University of Texas at San Antonio San Antonio, TX 78249, USA; School of Health Science and Healthcare Administrations, University of Atlanta, 6685 Peachtree Industrial Blvd, Atlanta, GA 30360, USA

Abstract: A study was done on 35 medically ill patients (20 male, 15 female) with an average age of 71.05 with mild dementia and depression in order to evaluate the efficacy of an integrative treatment approach on cognitive performance. These patients were evaluated at baseline and after 6, 12, and 24 months of treatment, which included antidepressants (Sertraline, Citalopram, or Venlafaxine XR, alone or in combination with Bupropion XR), cholinesterase inhibitors (Donepezil, Rivastigmine or Galantamine), as well as vitamins and supplements (Multivitamins , Vitamin E, AlphaLipoic Acid, Omega 3 and Coenyzme Q-10). Patients were encouraged to modify their diet and lifestlye and perform mild physical exercises. Results show that the integrative treatment not only protracted cognitive decline for 24 months, but even improved cognition, especially memory and frontal live functions.